New data refute the long-prevailing belief that PbW contributes little to children’s blood lead (PbB), it is likely to contribute 50% or more. (2) SiFW has been shown to interfere with
cholinergic function. Unlike the fully ionized state of fluoride (F-) in water treated with sodium fluoride (NaFW), the SiF anion, [SiF6]2- in SiFW
releases F- in a complicated dissociation process. Small amounts of incompletely dissociated [SiF6]2- or low molecular weight (LMW) silicic acid
(SA) oligomers may remain in SiFW. A German PhD study found that SiFW is a more powerful inhibitor of acetylcholinesterase (AChE) than
NaFW. It is proposed here that SiFW induces protein mis-folding via a mechanism that would affect polypeptides in general, and explain dental
fluorosis, a tooth enamel defect that is not merely ‘‘cosmetic’’ but a ‘‘canary in the mine’’ foretelling other adverse, albeit subtle, health and
behavioral effects. Efforts to refute evidence of such effects are analyzed and rebutted. In 1999 and 2000, senior EPA personnel admitted they knew
of no health effects studies of SiFs. In 2002 SiFs were nominated for NTP animal testing. In 2006 an NRC Fluoride Study Committee
recommended such studies. It is not known at this writing whether any had begun.
